Development of the mouse lung initiates on day 9.5 postcoitum from the laryngotracheal
groove and involves mesenchymal-epithelial interactions, in particular, those between the …

The vertebrate lung consists of multiple cell types that are derived primarily from endodermal
and mesodermal compartments of the early embryo. The process of pulmonary …

Classical studies using epithelial‐mesenchymal recombinants have identified basic rules of
how tissue interactions regulate patterning of developing branching structures such as the …

Lung morphogenesis requires the integration of multiple regulatory factors, which results in
a functional air-blood interface required for gas exchange at birth. The respiratory tract is …

Each of the steps of respiratory system development relies on intricate interactions and
coordinated development of the lung epithelium and mesenchyme. In the past, more …

Development of the pulmonary system is essential for terrestrial life. The molecular
pathways that regulate this complex process are beginning to be defined, and such …

Background: Mammalian lung development consists of a series of precisely choreographed
events that drive the progression from simple lung buds to the elaborately branched organ …

▪ Abstract Classical experiments in embryology have shown that normal growth,
morphogenetic patterning, and cellular differentiation in the developing lung depend on …

To form a diffusible interface large enough to conduct respiratory gas exchange with the
circulation, the lung endoderm undergoes extensive branching morphogenesis and …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …