Setting the cytokine trap for autoimmunity

CA Dinarello - Nature Medicine, 2003 - nature.com
Agents that block the action of specific cytokines have changed the lives of many patients
with rheumatoid arthritis and other autoimmune disorders. But frequent self-injections or …

Suppressing the self in rheumatoid arthritis

RS Mittler - Nature Medicine, 2004 - nature.com
Suppressing the self in rheumatoid arthritis | Nature Medicine Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Targeting cytokines to treat autoimmunity

VC Kyttaris - Clinical Immunology, 2019 - Elsevier
Monoclonal antibodies, small molecules and soluble receptors that target cytokines have
revolutionized the treatment of autoimmune and autoinflammatory diseases. The articles that …

Design of effective immunotherapy for human autoimmunity

M Feldmann, L Steinman - Nature, 2005 - nature.com
A better understanding of the molecules involved in immune responses has identified many
potential targets for the treatment of autoimmune diseases. But although successful …

Immune therapy for autoimmune diseases

L Steinman - Science, 2004 - science.org
Our increasing understanding of the pathophysiology of autoimmune disease has revealed
a number of checkpoints that can be targeted with immune therapy, including key mediators …

Autoimmune disease

R Hodson - Nature, 2021 - nature.com
The complex network of cells and proteins that make up our immune system is an invaluable
ally. Foreign invaders that would do us harm, such as viruses, are subject to intense assault …

Translating molecular insights in autoimmunity into effective therapy

M Feldmann - Annual review of immunology, 2009 - annualreviews.org
Autoimmunity and the pathogenesis of autoimmune diseases were a major focus of the
Walter and Eliza Hall Institute, where I started my research career. After my initial studies on …

Targeting cytokines in autoimmunity: new approaches, new promise

E Andreakos - Expert Opinion on Biological Therapy, 2003 - Taylor & Francis
The increasing understanding of the pathophysiology of a number of human autoimmune
diseases, and the realisation that cytokines play a major role, has provided the …

Autoimmune disease: why and where it occurs

P Marrack, J Kappler, BL Kotzin - Nature medicine, 2001 - nature.com
Autoimmune disease: why and where it occurs | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

The problems and promises of research into human immunology and autoimmune disease

BO Roep, J Buckner, S Sawcer, R Toes, F Zipp - Nature medicine, 2012 - nature.com
Translational research in autoimmunity is hampered by a number of hurdles, including a
lack of knowledge regarding initiating and pathologically relevant autoantigens, the low …