Myoendothelial gap junction frequency does not account for sex differences in EDHF responses in rat MCA

EM Sokoya, AR Burns, SP Marrelli, J Chen - Microvascular research, 2007 - Elsevier
Previous findings from our laboratory have shown that dilations to endothelium-derived
hyperpolarizing factor (EDHF) in rat middle cerebral artery (MCA) are less in females …

Evidence for the involvement of myoendothelial gap junctions in EDHF-mediated relaxation in the rat middle cerebral artery

EM Sokoya, AR Burns, CT Setiawan… - American Journal …, 2006 - journals.physiology.org
The mechanisms underlying endothelium-dependent hyperpolarizing factor (EDHF) in the
middle cerebral artery (MCA) remain largely unresolved. In particular, very little is known …

Incidence of myoendothelial gap junctions in the proximal and distal mesenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor …

SL Sandow, CE Hill - Circulation research, 2000 - Am Heart Assoc
Although the chemical nature of endothelium-derived hyperpolarizing factor (EDHF) remains
elusive, electrophysiological evidence exists for electrical communication between smooth …

Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor

SL Sandow, M Tare, HA Coleman, CE Hill… - Circulation …, 2002 - Am Heart Assoc
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …

Signaling across myoendothelial gap junctions—fact or fiction?

C de Wit, M Boettcher, VJ Schmidt - Cell communication & …, 2008 - Taylor & Francis
Gap junctions interconnect vascular cells homocellularly, thereby allowing the spread of
signals along the vessel wall, which serve to coordinate vessel behavior. In addition, gap …

Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery

SL Sandow, K Goto, NM Rummery… - The Journal of …, 2004 - Wiley Online Library
A role for myoendothelial gap junctions (MEGJs) has been proposed in the action of the
vasodilator endothelium‐derived hyperpolarizing factor (EDHF). EDHF activity varies in …

Endothelium‐derived hyperpolarizing factor: Is there a novel chemical mediator?

CR Triggle, H Ding - Clinical and Experimental Pharmacology …, 2002 - Wiley Online Library
Endothelium‐derived hyperpolarization (EDH) has been reported in many vessels and an
extensive literature suggests that a novel, non‐nitric oxide and non‐prostanoid, endothelium …

[HTML][HTML] Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective

K Schmidt, C De Wit - Frontiers in Physiology, 2020 - frontiersin.org
The endothelium controls vascular tone adopting blood flow to tissue needs. It releases
chemical mediators [eg, nitric oxide (NO), prostaglandins (PG)] and exerts appreciable …

Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo

D Siegl, M Koeppen, SE Wölfle, U Pohl… - Circulation …, 2005 - Am Heart Assoc
A smooth muscle hyperpolarization is essential for endothelium-dependent hyperpolarizing
factor–mediated dilations. It is debated whether the hyperpolarization is induced by a factor …

[HTML][HTML] Role of estrogen in modulating EDHF-mediated dilations in the female rat middle cerebral artery

EM Golding, TE Kepler - American Journal of Physiology …, 2001 - journals.physiology.org
We tested the hypothesis that endothelium-derived hyperpolarizing factor (EDHF) plays a
less dominant role in the female cerebrovasculature. The contribution of EDHF to the ATP …