Background Inflammation is a key hallmark of ALI and is mediated through ungoverned
cytokine signaling. One such cytokine, interleukin-1beta (IL-1β) has been demonstrated to …

Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy.
Protective actions were recently uncovered for docosahexaenoic acid-derived mediators …

Acute lung injury (ALI), which presents as acute respiratory failure, is a major clinical
problem that requires aggressive care, and patients who require prolonged oxygen …

Introduction Pulmonary fibrosis is a destructive, progressive disease that dramatically
reduces life quality of patients, ultimately leading to death. Therapeutic regimens for …

Abstract Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic
acid, has been reported to promote a biphasic activity in anti-inflammatory response and …

Acute lung injury is a life-threatening condition caused by disruption of the alveolar-capillary
barrier leading to edema, influx of inflammatory leukocytes, and impaired gas exchange …

Background A variety of inflammatory mediators and effector cells participate together in
acute lung injury, and lead to secondary injury that is due to an inflammatory cascade and …

In recent years, various studies have demonstrated a role for endogenously derived
specialized proresolving mediators such as resolvins in the resolution of inflammation. In …

Background Docosahexaenoic acid (DHA) and DHA-derived lipid mediators have recently
been shown to possess anti-inflammatory and pro-resolving properties. In fact, DHA can …

As one of the basic treatment modalities in the intensive care unit (ICU), mechanical
ventilation can cause or aggravate acute lung injury or ventilator‐induced lung injury (VILI) …