[PDF][PDF] Kinins and cytokines in COVID-19: a comprehensive pathophysiological approach
F van de Veerdonk, MG Netea, M van Deuren… - 2020 - pdfs.semanticscholar.org
Most striking observations in COVID-19 patients are the hints on pulmonary edema (also
seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more …
seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more …
Safety and outcomes associated with the pharmacological inhibition of the kinin–kallikrein system in severe COVID-19
E Mansour, AC Palma, RG Ulaf, LC Ribeiro… - Viruses, 2021 - mdpi.com
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
Angioedema in COVID-19
AJ Cohen, MF DiFrancesco, SD Solomon… - European Heart …, 2020 - academic.oup.com
A 62-year-old man with a history of hypertension presented with 12 h of lip and facial
swelling. Twelve days prior to presentation, he developed fevers (up to 39 C), chills, fatigue …
swelling. Twelve days prior to presentation, he developed fevers (up to 39 C), chills, fatigue …
Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID‐19
The COVID‐19 pandemic is rapidly spreading, and health care systems are being
overwhelmed with the huge number of cases, with a good number of cases requiring …
overwhelmed with the huge number of cases, with a good number of cases requiring …
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
FL van de Veerdonk, MG Netea, M van Deuren… - Elife, 2020 - elifesciences.org
COVID-19 patients can present with pulmonary edema early in disease. We propose that
this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) …
this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) …
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
VT Karamyan - Physiological Reports, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with …
syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with …
What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease with fast spreading
all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute …
all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute …
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
[HTML][HTML] A new storm on the horizon in COVID-19: Bradykinin-induced vascular complications
CG McCarthy, S Wilczynski, CF Wenceslau… - Vascular …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) virus has taken an immeasurable toll on humanity, with the …
coronavirus 2 (SARS-CoV-2) virus has taken an immeasurable toll on humanity, with the …
SARS-CoV-2 receptor is co-expressed with elements of the kinin–kallikrein, renin–angiotensin and coagulation systems in alveolar cells
Abstract SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …