The cellular response to treatment with proinflammatory cytokines or exposure to
environmental stress is mediated, in part, by the p38 group of mitogen-activated protein …

Figure 1 p38 mitogen-activated protein kinases (MAPKs) in mammalian cells. The four p38
MAPKs are 60–70% identical in their amino acid sequence. The MAPK kinase MKK6 is a …

All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family
(p38α, p38β, p38γ and p38δ) are activated by dual phosphorylation in the TGY motif in the …

We have investigated the ability of the mitogen-activated protein kinase (MAPK) kinase
MKK6 to activate different members of the p38 subfamily of MAPKs and found that some …

The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different
protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein …

The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by
proinflammatory cytokines and environmental stress. The detection of p38 MAP kinase in the …

Mitogen-activated protein (MAP) kinase cascades represent one of the major signal systems
used by eukaryotic cells to transduce extracellular signals into cellular responses. Four MAP …

The p38 mitogen-activated protein kinase is activated by treatment of cells with cytokines
and by exposure to environmental stress. The effects of these stimuli on p38 MAP kinase are …

The p38 mitogen-activated protein kinase (MAPK) group is represented by four isoforms in
mammals (p38α, p38β2, p38γ and p38δ). These p38 MAPK isoforms appear to mediate …

The p38 signaling pathway is activated in response to cell stress and induces production of
proinflammatory cytokines. P38α is phosphorylated and activated in response to cell stress …