Neurons fail to regenerate following spinal cord injury partly due to the up‐regulation of
chondroitin sulfate proteoglycans (CSPGs). Animal models of neuronal injury show …

Chondroitin sulfate proteoglycans (CSPGs) present a formidable barrier to regrowing axons
following spinal cord injury. CSPGs are secreted in response to injury and their …

Chondroitin sulfate proteoglycans (CSPGs) are up‐regulated following spinal cord injury
and are partly responsible for failed regeneration. Experimental paradigms in vivo that …

The bacterial enzyme chondroitinase ABC (ChABC), which cleaves chondroitin sulfate
glycosaminoglycan chains, can degrade inhibitory scar tissue formed following spinal cord …

Spinal cord injury (SCI) can lead to permanent paralysis below the level of injury.
Environmental factors within the injured spinal cord have been shown to strongly participate …

Injury to the CNS of vertebrates leads to the formation of a glial scar and production of
inhibitory molecules, including chondroitin sulphate proteoglycans. Various studies suggest …

Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …

Chondroitin sulphate proteoglycans (CSPGs) are known to be important contributors to the
intensely inhibitory environment that prevents tissue repair and regeneration following …

CNS lesions induce production of ECM molecules that inhibit axon regeneration. One major
inhibitory family is the chondroitin sulfate proteoglycans (CSPGs). Reduction of their …