Molecular basis of electrical remodeling in atrial fibrillation

DR Van Wagoner, JM Nerbonne - Journal of molecular and cellular …, 2000 - Elsevier
DR Van Wagoner and JM Nerbonne. Molecular Basis of Electrical Remodeling in Atrial
Fibrillation. Journal of Molecular and Cellular Cardiology (2000) 32, 1101–1117. Atrial …

Molecular mechanisms of remodeling in human atrial fibrillation

BJJM Brundel, RH Henning… - Cardiovascular …, 2002 - academic.oup.com
An important acknowledgement of the last several years is that atrial fibrillation (AF) modifies
the electrical properties of the atrium in a way that promotes its occurrence and …

Electrical remodeling in atrial fibrillation

D Dobrev - Herz, 2006 - search.proquest.com
Electrical remodeling refers to any change in electrical function that promotes atrial
fibrillation (AF). A key advance in understanding the mechanisms of AF has been the …

Electrophysiological remodeling in human atrial fibrillation

DRV Wagoner - Pacing and clinical electrophysiology, 2003 - Wiley Online Library
Atrial fibrillation (AF) is a progressive disease characterized by cumulative
electrophysiological and structural remodeling of the atria. Cellular electrophysiological …

Remodeling of cardiomyocyte ion channels in human atrial fibrillation

D Dobrev, U Ravens - Basic research in cardiology, 2003 - Springer
This review is focused on electrical adaptational processes in patients with chronic AF.
Cellular electrical remodeling includes shortening of action potential duration and effective …

Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation

S Nattel - Cardiovascular research, 1999 - academic.oup.com
One of the most exciting developments in our understanding of atrial fibrillation (AF) over the
last several years has been the recognition that AF itself modifies atrial electrical properties …

Ionic remodeling in the heart: pathophysiological significance and new therapeutic opportunities for atrial fibrillation

S Nattel, D Li - Circulation research, 2000 - Am Heart Assoc
Heart disease has long been recognized to alter cardiac electrical function. Detailed studies
of disease-induced remodeling of ionic transport processes that underlie ventricular …

Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics

D Dobrev, S Nattel - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial electrical and structural alterations (remodeling) have emerged as key elements in the
development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in …

Ionic mechanisms of electrical remodeling in human atrial fibrillation

RF Bosch, X Zeng, JB Grammer… - Cardiovascular …, 1999 - academic.oup.com
Objectives: Atrial fibrillation (AF) is associated with a decrease in atrial ERP and ERP
adaptation to rate as well as changes in atrial conduction velocity. The cellular changes in …

Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …