Hematopoietic transcription factors are involved in chromosomal translocations, which
generate fusion proteins contributing to leukemia pathogenesis. Analysis of patient's primary …

MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a
genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with …

Abstract t (8; 21) is one of the most frequent chromosomal translocations occurring in acute
myeloid leukemia (AML) and is considered the leukemia-initiating event. The biologic and …

It is generally assumed that gain-and loss-of-function manipulations of a functionally
important gene should lead to the opposite phenotypes. We show in this study that both …

Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies
with variable response to treatment. AMLs bearing MLL (mixed lineage leukemia) …

Transcription factor CCAAT enhancer binding protein α (C/EBPα) is essential for
granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master …

microRNA-223 (miR-223) can trigger normal granulopoiesis. miR-223 expression is
regulated by two distinct CEBPA (CCAAT/enhancer binding protein-alpha) sites. Here, we …

MicroRNAs (miRNAs), small noncoding RNAs that regulate target gene mRNAs, are known
to contribute to pathogenesis of cancers. Acute myeloid leukemia (AML) is a group of …

Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid
lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate …

Alteration of lineage-specific transcriptional programs for hematopoiesis causes
differentiation block and promotes leukemia development. Here, we show that AML1/ETO …