Immune system-mediated cellular and molecular mechanisms in idiopathic membranous nephropathy pathogenesis and possible therapeutic targets

R Motavalli, J Etemadi, H Kahroba, A Mehdizadeh… - Life sciences, 2019 - Elsevier
Idiopathic membranous nephropathy (IMN) has recently attracted much attention due to the
development of auto antibodies, anti-phospholipase A2 receptor and anti-thrombospondin …

Cytokines network in primary membranous nephropathy

Q Zhao, H Dai, Y Hu, H Jiang, Z Feng, W Liu… - International …, 2022 - Elsevier
There have been extensive studies on the immunological mechanism of primary
membranous nephropathy (PMN). Autoantibodies, being the end product of humoral auto …

Idiopathic membranous nephropathy: glomerular pathological pattern caused by extrarenal immunity activity

W Liu, C Gao, Z Liu, H Dai, Z Feng, Z Dong… - Frontiers in …, 2020 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is a pathological pattern of glomerular damage
caused by an autoimmune response. Immune complex deposition, thickness of glomerular …

Membranous nephropathy: mechanistic insights and therapeutic perspectives

MR Hua, YL Zhao, JZ Yang, L Zou, YY Zhao… - International …, 2023 - Elsevier
Membranous nephropathy (MN) is one of the most common causes of non-diabetic
nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20 …

[HTML][HTML] Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy

AKI Kuroki, M Iyoda, T Shibata, T Sugisaki - Kidney International, 2005 - Elsevier
Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous
nephropathy. Background The predominant deposition of IgG4 in idiopathic membranous …

B cells in primary membranous nephropathy: escape from immune tolerance and implications for patient management

BYF So, DYH Yap, TM Chan - International Journal of Molecular Sciences, 2021 - mdpi.com
Membranous nephropathy (MN) is an important cause of nephrotic syndrome and chronic
kidney disease (CKD) in adults. The pathogenic significance of B cells in MN is increasingly …

Revisiting immunological and clinical aspects of membranous nephropathy

I Nieto-Gañán, I Iturrieta-Zuazo, C Rita… - Clinical …, 2022 - Elsevier
Idiopathic or primary membranous nephropathy (IMN) is one of the most frequent causes of
nephrotic syndrome in adults and the elderly. It is characterized by a thickening of the wall of …

Identification of biomarkers related to immune and inflammation in membranous nephropathy: comprehensive bioinformatic analysis and validation

P Zhang, Y Geng, J Tang, Z Cao, X Xiang… - Frontiers in …, 2023 - frontiersin.org
Background Membranous nephropathy (MN) is an autoimmune glomerular disease that is
predominantly mediated by immune complex deposition and complement activation. The …

Advances of the experimental models of idiopathic membranous nephropathy

HX Jiang, Z Feng, ZB Zhu, CH Xia… - Molecular …, 2020 - spandidos-publications.com
Idiopathic membranous nephropathy (IMN) is one of the main types of chronic kidney
disease in adults and one of the most common causes of end‑stage renal disease. In recent …

Immunopathogenesis of membranous nephropathy: an update

H Debiec, P Ronco - Seminars in immunopathology, 2014 - Springer
Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease
which affects the kidney glomerulus, resulting in the formation of immune deposits on the …