The optimal goal for pathologists is to provide important information to clinicians in order to
predict tumor biology. Specific morphologic features may serve as predictive markers of …

Pituitary adenomas represent an inhomogenous tumor entity in terms of growth rate,
invasiveness and recurrence. To improve understanding of their different biological …

Context.—The sellar region is the site of frequent pathology. The pituitary is affected by a
large number of pathologic entities arising from the gland itself and from adjacent …

The 4th edition of the World Health Organization (WHO) classification of endocrine tumors
has been recently released. In this new edition, major changes are recommended in several …

This review summarizes the changes in the 5th Edition of the WHO Classification of
Endocrine and Neuroendocrine Tumors that relate to the pituitary gland. The new …

Several new markers have shown a capacity to predict the clinicopathological behavior of
pituitary neoplasms; these markers have shown potential to correlate with tumor subtype …

Pituitary adenomas are currently classified by histological, immunocytochemical and
numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We …

Purpose Tumor immune microenvironment in pituitary neuroendocrine tumors (PitNETs) and
application of current immunotherapy for refractory PitNETs remains debated. We aim to …

Objectives Microarray technology allows for the expression profile of many thousands of
genes to be quantified at the same time, and has resulted in novel discoveries about the …

Pituitary neuroendocrine tumors (PitNETs) are common, with five main histological subtypes:
lactotroph, somatotroph, and thyrotroph (POU1F1/PIT1 lineage); corticotroph (TBX19/TPIT …