[HTML][HTML] Glucagon-like peptide 1 (GLP-1)

TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Glucagon‐like peptide‐1 (GLP‐1)‐based therapeutics: current status and future opportunities beyond type 2 diabetes

JY Cheang, PM Moyle - ChemMedChem, 2018 - Wiley Online Library
Abstract Glucagon‐like peptide‐1 (GLP‐1) is secreted by intestinal L‐cells following food
intake, and plays an important role in glucose homeostasis due to its stimulation of glucose …

Therapeutic strategies based on glucagon-like peptide 1

CF Deacon - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent
insulinotropic and glucagonostatic actions, trophic effects on the pancreatic β-cells, and …

Glucagon-like peptide 1 (GLP-1): an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential

JJ Holst - Trends in Endocrinology & Metabolism, 1999 - cell.com
The incretin hormone, glucagon-like peptide 1 (GLP-1) has many actions; namely:(1) it
enhances all steps of insulin biosynthesis and potentiates glucose-induced secretion;(2) it …

Glucagon-like peptide-1: glucose homeostasis and beyond

YM Cho, Y Fujita, TJ Kieffer - Annual review of physiology, 2014 - annualreviews.org
Glucagon-like peptide-1 (GLP-1), an incretin hormone secreted primarily from the intestinal
L-cells in response to meals, modulates nutrient homeostasis via actions exerted in multiple …

Glucagon‐like peptide 1 (GLP‐1) in biology and pathology

JJ Meier, MA Nauck - Diabetes/metabolism research and …, 2005 - Wiley Online Library
Post‐translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon‐like peptide 1 (GLP‐1). Owing to its glucose‐dependent …

GLP‐1: physiological effects and potential therapeutic applications

K Aaboe, T Krarup, S Madsbad… - Diabetes, Obesity and …, 2008 - Wiley Online Library
Glucagon‐like peptide 1 (GLP‐1) is a gut‐derived incretin hormone with the potential to
change diabetes. The physiological effects of GLP‐1 are multiple, and many seem to …

Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes

LB Knudsen - Journal of medicinal chemistry, 2004 - ACS Publications
Type 2 diabetes is increasingly becoming a worldwide epidemic. Currently there is much
focus on the glucagon-like peptide-1 (GLP-1) peptide hormone as the basis for a potential …

Minireview: update on incretin biology: focus on glucagon-like peptide-1

PL Brubaker - Endocrinology, 2010 - academic.oup.com
The incretin hormone, glucagon-like peptide-1 (GLP-1), is now being used in the clinic to
enhance insulin secretion and reduce body weight in patients with type 2 diabetes. Although …

Glucagon-like peptide-1 and glucagon-like peptide-2

LL Baggio, DJ Drucker - Best Practice & Research Clinical Endocrinology & …, 2004 - Elsevier
The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2
(GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 …