Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays
of 1–6 base pair sequence motifs, that comprise a substantial fraction of the human genome …

Over a third of the human genome is comprised of repetitive sequences, including more than
a million short tandem repeats (STRs). While studies of the pathologic consequences of …

Tandem repeats represent one of the most abundant class of variations in human genomes,
which are polymorphic by nature and become highly unstable in a length-dependent …

Tandem repeat DNA sequences constitute a significant proportion of the human genome.
While previously considered to be functionally inert, these sequences are now broadly …

Abstract Short Tandem Repeats (STRs) comprise repeats of one to several base pairs.
Because of the high mutability due to strand slippage during DNA synthesis, rapid …

The pathological expansion of unstable trinucleotide repeats currently is known to cause 14
neurological diseases. Over the past several years, researchers have concentrated on the …

The human genome contains numerous genetic polymorphisms contributing to different
health and disease outcomes. Tandem repeat (TR) loci are highly polymorphic yet under …

Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic.
These can present with overlapping clinical phenotypes, making molecular diagnosis …

Tandem repeats are common features of both prokaryote and eukaryote genomes, where
they can be found not only in intergenic regions but also in both the noncoding and coding …

Background Short tandem repeat (STR) expansion disorders are an important cause of
human neurological disease. They have an established role in more than 40 different …