Sepsis is a life-threatening illness that occurs due to an abnormal host immune network
which extends through the initial widespread and overwhelming inflammation, and …

Regulated cell death is defined as genetically encoded pathways that lead towards the
demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Sepsis with subsequent multiple-organ dysfunction is a distinct systemic inflammatory
response to concealed or obvious infection, and it is a leading cause of death in intensive …

Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

Today, despite the application of contemporary operative/pharmacological approaches in
the treatment of the critically ill trauma/surgery patient, we are still faced with a high …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

Members of the caspase family of cysteine proteases have been firmly established to play
key roles in signal transduction cascades that culminate in apoptosis (programmed cell …