The RNA-binding protein HuR is a negative regulator in adipogenesis
DTC Siang, YC Lim, AMM Kyaw, KN Win… - Nature …, 2020 - nature.com
Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in
metabolism remains unclear. This study identifies HuR as a major repressor during …
metabolism remains unclear. This study identifies HuR as a major repressor during …
Adipose HuR protects against diet-induced obesity and insulin resistance
J Li, L Gong, S Liu, Y Zhang, C Zhang, M Tian… - Nature …, 2019 - nature.com
Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is
involved in many physiological processes. Obesity, as a worldwide healthcare problem, has …
involved in many physiological processes. Obesity, as a worldwide healthcare problem, has …
RNA-binding proteins in the regulation of adipogenesis and adipose function
P Zhang, W Wu, C Ma, C Du, Y Huang, H Xu, C Li… - Cells, 2022 - mdpi.com
The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204
Adipogenesis is a complex and precisely orchestrated process mediated by a network of
adipogenic regulatory factors. Several studies have highlighted the relevance of lncRNAs in …
adipogenic regulatory factors. Several studies have highlighted the relevance of lncRNAs in …
Micro RNA‐455 regulates brown adipogenesis via a novel HIF 1an‐AMPK‐PGC 1α signaling network
H Zhang, M Guan, KL Townsend, TL Huang, D An… - EMBO …, 2015 - embopress.org
Brown adipose tissue (BAT) dissipates chemical energy as heat and can counteract obesity.
Micro RNA s are emerging as key regulators in development and disease. Combining micro …
Micro RNA s are emerging as key regulators in development and disease. Combining micro …
[HTML][HTML] RNA-binding protein HuD controls insulin translation
EK Lee, W Kim, K Tominaga, JL Martindale, X Yang… - Molecular cell, 2012 - cell.com
Although expression of the mammalian RNA-binding protein HuD was considered to be
restricted to neurons, we report that HuD is present in pancreatic β cells, where its levels are …
restricted to neurons, we report that HuD is present in pancreatic β cells, where its levels are …
[HTML][HTML] Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K
How body size is determined is a long-standing question in biology, yet its regulatory
mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and …
mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and …
The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in
governing metabolic homeostasis is less understood. Here, we describe a human adipocyte …
governing metabolic homeostasis is less understood. Here, we describe a human adipocyte …
Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis
In this study, we explored the roles of microRNAs in adipocyte differentiation and
metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the processing of …
metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the processing of …
RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling
Y Lustig, E Barhod, R Ashwal-Fluss, R Gordin… - Diabetes, 2014 - Am Diabetes Assoc
Adiponectin receptor 1 (AdipoR1) mediates adiponectin's pleiotropic effects in muscle and
liver and plays an important role in the regulation of insulin resistance and diabetes. Here …
liver and plays an important role in the regulation of insulin resistance and diabetes. Here …