Streptococcus pyogenes malate degradation pathway links pH regulation and virulence

E Paluscio, MG Caparon - Infection and immunity, 2015 - Am Soc Microbiol
The ability of Streptococcus pyogenes to infect different niches within its human host most
likely relies on its ability to utilize alternative carbon sources. In examining this question, we …

[HTML][HTML] Streptococcus pyogenes metabolism

V Pancholi, M Caparon - Streptococcus pyogenes: Basic Biology to …, 2022 - ncbi.nlm.nih.gov
Streptococcus pyogenes (Group A Streptococcus/GAS or S. pyogenes) is endowed with a
formidable arsenal of virulence factors that allow it to evade host's innate immune responses …

A PTS EII mutant library in Group A Streptococcus identifies a promiscuous man‐family PTS transporter influencing SLS‐mediated hemolysis

GS Sundar, E Islam, K Gera, Y Le Breton… - Molecular …, 2017 - Wiley Online Library
Summary The Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram‐positive
human pathogen that must adapt to unique host environments in order to survive. Links …

[图书][B] Adaptive mechanisms to niche remodeling in Streptococcus pyogenes

E Paluscio - 2015 - search.proquest.com
Abstract The Gram-positive bacterium Streptococcus pyogenes is a remarkably successful
pathogen, capable of infecting numerous tissue sites within its human host. The ability of S …

[PDF][PDF] Manganese homeostasis in group A

AG Turner, CL Ong, CM Gillen, MR Davies, NP West… - 2015 - academia.edu
Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen
responsible for a spectrum of human disease states. Metallobiology of human pathogens is …

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

AG Turner, CLY Ong, CM Gillen, MR Davies, NP West… - MBio, 2015 - Am Soc Microbiol
Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen
responsible for a spectrum of human disease states. Metallobiology of human pathogens is …

Spontaneous mutants of Streptococcus sanguinis with defects in the glucose-Phosphotransferase System show enhanced post-exponential-phase fitness

L Zeng, AR Walker, K Lee, ZA Taylor… - Journal of …, 2021 - Am Soc Microbiol
Genetic truncations in a gene encoding a putative glucose-phosphotransferase system
(PTS) protein (manL, EIIABMan) were identified in subpopulations of two separate …

Deletion of the L-Lactate Dehydrogenase Gene ldh in Streptococcus pyogenes Leads to a Loss of SpeB Activity and a Hypovirulent Phenotype

S Oehmcke-Hecht, LE Nass, JB Wichura… - Frontiers in …, 2017 - frontiersin.org
Streptococcus pyogenes uses lactic acid fermentation for the generation of ATP. Here, we
analyzed the impact of a deletion of the l-lactate dehydrogenase gene ldh on the virulence …

Different Roles of EIIABMan and EIIGlc in Regulation of Energy Metabolism, Biofilm Development, and Competence in Streptococcus mutans

J Abranches, MM Candella, ZT Wen… - Journal of …, 2006 - Am Soc Microbiol
The phosphoenolpyruvate: sugar phosphotransferase system (PTS) is the major
carbohydrate transport system in oral streptococci. The mannose-PTS of Streptococcus …

The phosphoenolpyruvate phosphotransferase system in group A Streptococcus acts to reduce streptolysin S activity and lesion severity during soft tissue infection

K Gera, T Le, R Jamin, Z Eichenbaum… - Infection and …, 2014 - Am Soc Microbiol
Obtaining essential nutrients, such as carbohydrates, is an important process for bacterial
pathogens to successfully colonize host tissues. The phosphoenolpyruvate …