Epithelial-mesenchymal transition: An emerging target in tissue fibrosis

M Li, F Luan, Y Zhao, H Hao, Y Zhou… - Experimental biology …, 2016 - journals.sagepub.com
Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses.
Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive …

Molecular requirements for epithelial–mesenchymal transition during tumor progression

MA Huber, N Kraut, H Beug - Current opinion in cell biology, 2005 - Elsevier
Epithelial–mesenchymal transitions (EMTs) occur as key steps during embryonic
morphogenesis, and are now implicated in the progression of primary tumors towards …

[HTML][HTML] Crosstalk of oncogenic signaling pathways during epithelial–mesenchymal transition

S Lindsey, SA Langhans - Frontiers in oncology, 2014 - frontiersin.org
Epithelial–mesenchymal transition (EMT) and cell transformation have been well-
documented in multiple cancer cell models and are believed to be one of the earliest events …

Epithelial-mesenchymal transition

DC Radisky - Journal of cell science, 2005 - journals.biologists.com
Induction of EMT appears to be highly tissue-and cell type-specific (Thiery, 2003), because
factors that induce EMT under some circumstances can have quite different effects in others …

[HTML][HTML] Emerging concepts of hybrid epithelial-to-mesenchymal transition in cancer progression

D Sinha, P Saha, A Samanta, A Bishayee - Biomolecules, 2020 - mdpi.com
Epithelial mesenchymal transition (EMT) is a complex process through which epithelial (E)
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …

The EMT universe: space between cancer cell dissemination and metastasis initiation

L Ombrato, I Malanchi - Critical Reviews™ in Oncogenesis, 2014 - dl.begellhouse.com
Tumor metastasis, the cause of more than 90% of cancer cell mortality, is a multistep
process by which tumor cells disseminate from their primary site via local invasion and …

[HTML][HTML] The epithelial-to-mesenchymal transition in development and cancer

A Francou, KV Anderson - Annual review of cancer biology, 2020 - annualreviews.org
Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells
undergo dramatic changes in signaling, transcriptional programming, and cell shape, while …

[HTML][HTML] Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis

H Škovierová, T Okajčeková… - International …, 2018 - spandidos-publications.com
Numerous studies over the past two decades have focused on the epithelial‑to‑
mesenchymal transition (EMT) and its role in the development of metastasis. Certain studies …

[HTML][HTML] EMT subtype influences epithelial plasticity and mode of cell migration

NM Aiello, R Maddipati, RJ Norgard, D Balli, J Li… - Developmental cell, 2018 - cell.com
Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and
metastasis. EMT is thought to be regulated primarily at the transcriptional level through the …

[HTML][HTML] Novel clinical therapeutics targeting the epithelial to mesenchymal transition

AN Kothari, Z Mi, M Zapf, PC Kuo - Clinical and translational medicine, 2014 - Springer
The epithelial to mesenchymal transition (EMT) is implicated in many processes, ranging
from tissue and organogenesis to cancer and metastatic spread. Understanding the key …