Retrospective study of regorafenib and trifluridine/tipiracil efficacy as a third‑line or later chemotherapy regimen for refractory metastatic colorectal cancer

A Tanaka, S Sadahiro, T Suzuki… - Oncology …, 2018 - spandidos-publications.com
Regorafenib and trifluridine/tipiracil (TAS-102) are novel antitumor agents for patients with
refractory metastatic colorectal cancer. However, it is unclear which patients may derive a …

Regorafenib versus trifluridine/tipiracil for refractory metastatic colorectal cancer: a retrospective comparison

T Masuishi, H Taniguchi, S Hamauchi, A Komori… - Clinical Colorectal …, 2017 - Elsevier
Background Regorafenib and trifluridine/tipiracil (TAS-102) both prolong survival for patients
with refractory metastatic colorectal cancer. However, it is unclear which drug should be …

A real-world comparison of regorafenib and trifluridine/tipiracil in refractory metastatic colorectal cancer in the United States

C Nevala-Plagemann, S Sama, J Ying, J Shen… - Journal of the National …, 2023 - jnccn.org
Background: Trifluridine/Tipiracil (TAS-102) and regorafenib are FDA-approved in the
United States for treatment of refractory metastatic colorectal cancer (mCRC). FDA approvals …

Efficacy and safety of regorafenib or TAS-102 in patients with metastatic colorectal cancer refractory to standard therapies

T Sueda, D Sakai, T Kudo, T Sugiura… - Anticancer …, 2016 - ar.iiarjournals.org
Background: Regorafenib and TAS-102 are novel antitumor agents for patients with
metastatic colorectal cancer (mCRC) whose disease has progressed after standard …

[HTML][HTML] Maximising clinical benefit with adequate patient management beyond the second line in mCRC

G Argiles, D Arnold, G Prager, AF Sobrero… - ESMO open, 2019 - Elsevier
New therapeutic options for refractory metastatic colorectal cancer (mCRC) include
trifluridine/tipiracil (TAS-102) and regorafenib. However, the optimal chemotherapeutic …

Prognostic scores for evaluating the survival benefit of regorafenib or trifluridine/tipiracil in patients with metastatic colorectal cancer: an exploratory analysis of the …

T Moriwaki, S Fukuoka, T Masuishi… - International Journal of …, 2020 - Springer
Background Although regorafenib or trifluridine/tipiracil (FTD/TPI) has been recognized as a
later-line standard treatment in patients with metastatic colorectal cancer (mCRC), not all …

Propensity score analysis of regorafenib versus trifluridine/tipiracil in patients with metastatic colorectal cancer refractory to standard chemotherapy (REGOTAS): a …

T Moriwaki, S Fukuoka, H Taniguchi… - The …, 2018 - academic.oup.com
Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD)
in patients with metastatic colorectal cancer (mCRC) who are refractory to standard …

Regorafenib vs trifluridine/tipiracil for metastatic colorectal cancer refractory to standard chemotherapies: a multicenter retrospective comparison study in Japan

M Ogata, M Kotaka, T Ogata, Y Hatachi, H Yasui… - PLoS …, 2020 - journals.plos.org
Regorafenib (REG) and trifluridine/tipiracil (FTD/TPI) showed survival benefits in metastatic
colorectal cancer patients previously treated with standard chemotherapies; therefore, we …

Safety and efficacy of trifluridine/tipiracil monotherapy in clinical practice for patients with metastatic colorectal cancer: experience at a single institution

D Kotani, K Shitara, A Kawazoe, S Fukuoka… - Clinical Colorectal …, 2016 - Elsevier
Background The combination drug TAS-102 is a novel oral nucleoside antitumor agent
containing trifluridine and tipiracil hydrochloride, which prevents the degradation of …

A systematic review and network meta‐analysis of regorafenib and TAS‐102 in refractory metastatic colorectal cancer

MB Sonbol, R Benkhadra, Z Wang, B Firwana… - The …, 2019 - academic.oup.com
Background Regorafenib at different dosing strategies and TAS‐102 are treatment options
for refractory metastatic colorectal cancer (mCRC). We aimed to evaluate the comparative …