Animal models of colorectal carcinogenesis represent invaluable research tool for
investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory …

The dimethyhydrazine (DMH) or azoxymethane (AOM) model is a well‐established, well‐
appreciated, and widely used model of experimental colon carcinogenesis. It has many …

dimethylhydrazine (DMH) is a member in the class of hydrazines, strong DNA alkylating
agent, naturally present in cycads. DMH is widely used as a carcinogen to induce colon …

Since its original description by Druckrey (1), the rodent model of colon cancer induced with
i, 2-dimethylhydrazine has become widely used in the study of colonic carcinogenesis. At …

Abstract AKR/J, SWR/J, P/J, C57BL/6J, and GR mice were given injections once a week for
20 weeks with 15 mg 1, 2-dimethylhydrazine (DMH)/kg body weight. Colorectal tumors …

The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in
NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver …

Preneoplastic mucosal changes were studied at six different time‐points during
dimethylhydrazine (DMH)‐induced colorectal carcinogenesis in the rat. After 40 weeks of …

In this study we have investigated the relationship between the dose of 1, 2-
dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain …

Abstract The mouse model of 1, 2-dimethylhydrazine (DMH)-induced colorectal
carcinogenesis was studied to determine the susceptibility of different anatomic segments of …

Colorectal tumor yield and volume data were obtained using 355 CF 1 mice serially
sacrificed up to 84 weeks following various dose levels of the carcinogen 1, 2 …