RIPC provides neuroprotection against ischemic stroke by suppressing apoptosis via the mitochondrial pathway

J Lv, W Guan, Q You, L Deng, Y Zhu, K Guo, X Gao… - Scientific Reports, 2020 - nature.com
Ischemic stroke is a common disease with high morbidity and mortality. Remote ischemic
preconditioning (RIPC) can stimulate endogenous protection mechanisms by inducing …

Limb remote ischemic post-conditioning mitigates brain recovery in a mouse model of ischemic stroke by regulating reactive astrocytic plasticity

X Cheng, H Zhao, F Yan, Z Tao, R Wang, Z Han, G Li… - Brain Research, 2018 - Elsevier
Maladaptive alterations of astrocytic plasticity may cause brain edema in the acute stage of
stroke and glial scar formation in the recovery stage. The present study was designed to …

[HTML][HTML] Remote postconditioning may attenuate ischaemia–reperfusion injury in the murine hindlimb through adenosine receptor activation

H Tsubota, A Marui, J Esaki, SC Bir, T Ikeda… - European Journal of …, 2010 - Elsevier
OBJECTIVE: This study aimed to determine the effect and mechanisms of remote
postconditioning (RPC) upon ischaemia–reperfusion injury (IRI) in the ischaemic mouse …

Short‐term remote ischemic conditioning may protect monkeys after ischemic stroke

L Guo, DA Zhou, DI Wu, J Ding, X He… - Annals of Clinical …, 2019 - Wiley Online Library
Objective We aimed to evaluate the safety and effectiveness of short‐term remote ischemic
postconditioning (RIPC) in acute stroke monkey models. Methods Acute stroke monkeys …

Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter

M Ezzati, A Bainbridge, KD Broad… - Journal of Cerebral …, 2016 - journals.sagepub.com
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention
whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in …

RiPerC Attenuates Cerebral Ischemia Injury through Regulation of miR‐98/PIK3IP1/PI3K/AKT Signaling Pathway

D Zhang, L Mei, R Long, C Cui, Y Sun… - Oxidative Medicine …, 2020 - Wiley Online Library
Background. Cerebral ischemic stroke is a refractory disease which seriously endangers
human health. Remote ischemic perconditioning (RiPerC) by which the sublethal ischemic …

Remote but not distant: a review on experimental models and clinical trials in remote ischemic conditioning as potential therapy in ischemic stroke

I Mollet, JP Marto, M Mendonça, MV Baptista… - Molecular …, 2022 - Springer
Stroke is one of the main causes of neurological disability worldwide and the second cause
of death in people over 65 years old, resulting in great economic and social burden …

Enhanced oxidative stress response and neuroprotection of combined limb remote ischemic conditioning and atorvastatin after transient ischemic stroke in rats

C Ren, S Li, K Liu, GB Rajah, A Zhang, R Han… - Brain …, 2017 - journals.lww.com
BACKGROUND: Limb remote ischemic conditioning (LRIC) and atorvastatin (AtS) both
provide neuroprotection in stroke. We evaluated the enhanced neuroprotective effect of …

Nrg1β released in remote ischemic preconditioning improves myocardial perfusion and decreases ischemia/reperfusion injury via ErbB2-mediated rescue of …

V Kundumani-Sridharan, J Subramani… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Remote ischemic preconditioning (RIPC) is an intervention process where the
application of multiple cycles of short ischemia/reperfusion (I/R) in a remote vascular bed …

A critical review of mechanisms regulating remote preconditioning-induced brain protection

R Meller, RP Simon - Journal of applied physiology, 2015 - journals.physiology.org
Remote preconditioning (rPC) is the phenomenon whereby brief organ ischemia evokes an
endogenous response such that a different (remote) organ is protected against subsequent …