Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

V Robert, L Therreau, V Chevaleyre, E Lepicard… - Elife, 2021 - elifesciences.org
The hippocampus is critical for memory formation. The hypothalamic supramammillary
nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 …

Hypothalamic supramammillary control of cognition and motivation

AJ Kesner, M Mozaffarilegha, KT Rajamani… - Journal of …, 2023 - Soc Neuroscience
The supramammillary nucleus (SuM) is a small region in the ventromedial posterior
hypothalamus. The SuM has been relatively understudied with much of the prior focus being …

REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation

H Qin, L Fu, T Jian, W Jin, M Liang, J Li, Q Chen… - Neuron, 2022 - cell.com
The hippocampal CA2 region plays a key role in social memory. The encoding of such
memory involves afferent activity from the hypothalamic supramammillary nucleus (SuM) to …

Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output

Y Hashimotodani, F Karube, Y Yanagawa, F Fujiyama… - Cell reports, 2018 - cell.com
The supramammillary nucleus (SuM) of the hypothalamus projects to the dentate gyrus (DG)
and the CA2 region of the hippocampus. Although the SuM-to-hippocampus circuits have …

Memory circuits: CA2

RA Piskorowski, V Chevaleyre - Current opinion in neurobiology, 2018 - Elsevier
The hippocampus is a central region in the coding of spatial, temporal and episodic memory.
Recent discoveries have revealed surprising and complex roles of the small area CA2 in …

Hypothalamic glutamate/GABA cotransmission modulates hippocampal circuits and supports long-term potentiation

MI Ajibola, JW Wu, WI Abdulmajeed… - Journal of …, 2021 - Soc Neuroscience
Subcortical input engages in cortico-hippocampal information processing. Neurons of the
hypothalamic supramammillary nucleus (SuM) innervate the dentate gyrus (DG) by …

Hippocampal CA1 circuitry dynamically gates direct cortical inputs preferentially at theta frequencies

CW Ang, GC Carlson, DA Coulter - Journal of Neuroscience, 2005 - Soc Neuroscience
Hippocampal CA1 pyramidal neurons receive intrahippocampal and extrahipppocampal
inputs during theta cycle, whose relative timing and magnitude regulate the probability of …

Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits

LY Prince, T Bacon, R Humphries… - PLoS Computational …, 2021 - journals.plos.org
In the hippocampus, episodic memories are thought to be encoded by the formation of
ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy …

CA2: A highly connected intrahippocampal relay

SJ Middleton, TJ McHugh - Annual Review of Neuroscience, 2020 - annualreviews.org
Although Lorente de No'recognized the anatomical distinction of the hippocampal Cornu
Ammonis (CA) 2 region, it had, until recently, been assigned no unique function. Its location …

Chronic loss of CA2 transmission leads to hippocampal hyperexcitability

R Boehringer, D Polygalov, AJY Huang, SJ Middleton… - Neuron, 2017 - cell.com
Hippocampal CA2 pyramidal cells project into both the neighboring CA1 and CA3 subfields,
leaving them well positioned to influence network physiology and information processing for …