High-fat diet-induced obesity and impairment of brain neurotransmitter pool

RSM Labban, H Alfawaz, AT Almnaizel… - Translational …, 2020 - degruyter.com
Obesity and the brain are linked since the brain can control the weight of the body through
its neurotransmitters. The aim of the present study was to investigate the effect of high-fat …

Diet-induced obesity causes hypothalamic neurochemistry alterations in Swiss mice

R de Bona Schraiber, AH de Mello, ML Garcez… - Metabolic brain …, 2019 - Springer
The aim of this study was to assess inflammatory parameters, oxidative stress and energy
metabolism in the hypothalamus of diet-induced obese mice. Male Swiss mice were divided …

High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation …

A Bittencourt, PO Brum, CT Ribeiro… - Nutritional …, 2022 - Taylor & Francis
Obesity is a health problem that has been associated with neuroinflammation, decreased
cognitive functions and development of neurodegenerative diseases. Parkinson's disease …

Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats

J Woo, KO Shin, SY Park, KS Jang, S Kang - Lipids in health and disease, 2013 - Springer
Background Nutritional imbalance-induced obesity causes a variety of diseases and in
particular is an important cause of cognitive function decline. This study was performed on …

Obesity-related brain cholinergic system impairment in high-fat-diet-fed rats

I Martinelli, SK Tayebati, P Roy… - Nutrients, 2022 - mdpi.com
A link between obesity and cerebral health is receiving growing recognition. Here, we
investigate in the frontal cortex and hippocampus the potential involvement of cholinergic …

The impact of vitamin D supplementation on neurodegeneration, TNF-α concentration in hypothalamus, and CSF-to-plasma ratio of insulin in high-fat-diet-induced …

G Nameni, G Hajiluian, P Shahabi, MA Farhangi… - Journal of Molecular …, 2017 - Springer
There is growing evidence that obesity can lead to neurodegeneration induced by pro-
inflammatory cytokines such as tumor necrosis factor (TNF-α). Moreover, obesity is …

Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level

S Nakajima, K Fukasawa, M Gotoh… - International Journal of …, 2020 - nature.com
Background Obesity is considered to be a risk factor for neurodegenerative-and psychiatric-
diseases including Alzheimer's disease, schizophrenia, and depression. A high-lard diet is …

Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats

G Hajiluian, M Abbasalizad Farhangi… - Nutritional …, 2018 - Taylor & Francis
Background: There is evidence that obesity leads to cognitive impairments via several
markers of oxidative stress including glutathione peroxidase (GPx), superoxide dismutase …

High-carbohydrate and fat diet consumption causes metabolic deterioration, neuronal damage, and loss of recognition memory in rats

E Fuentes, B Venegas, G Muñoz-Arenas… - Journal of chemical …, 2023 - Elsevier
The number of people diagnosed with metabolic syndrome (MetS) has increased
dramatically to reach alarming proportions worldwide. The origin of MetS derives from bad …

The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid

KA Amin, HH Kamel, MA Abd Eltawab - Lipids in health and disease, 2011 - Springer
Aims This study aimed to examine the effect of high fat diet (HFD) to modulate brain
dysfunction, and understand the linkages between obesity, metabolic disturbances and the …