Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities
The extent to which modifiable lifestyle factors offset the determined genetic risk of obesity
and obesity-related morbidities remains unknown. We explored how the interaction between …
and obesity-related morbidities remains unknown. We explored how the interaction between …
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study
Background We have previously shown that multiple genetic loci identified by genome-wide
association studies (GWAS) increase the susceptibility to obesity in a cumulative manner. It …
association studies (GWAS) increase the susceptibility to obesity in a cumulative manner. It …
Gene× physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry
Numerous obesity loci have been identified using genome-wide association studies. A UK
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …
study indicated that physical activity may attenuate the cumulative effect of 12 of these loci …
Gene–lifestyle interactions in obesity
Obesity is a complex multifaceted disease resulting from interactions between genetics and
lifestyle. The proportion of phenotypic variance ascribed to genetic variance is 0.4 to 0.7 for …
lifestyle. The proportion of phenotypic variance ascribed to genetic variance is 0.4 to 0.7 for …
Genes, lifestyles and obesity
OBJECTIVE: To review the role of genes and lifestyle factors, particularly dietary habits and
physical activity patterns, in obesity risk as well as their potential interactions. DESIGN AND …
physical activity patterns, in obesity risk as well as their potential interactions. DESIGN AND …
Impact of genes and environment on obesity and cardiovascular disease
Obesity and abdominal obesity have been closely related to cardiovascular outcomes, and
recent evidence has indicated that environmental and genetic factors act in concert in …
recent evidence has indicated that environmental and genetic factors act in concert in …
Gene× dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry
JA Nettleton, JL Follis, JS Ngwa… - Human molecular …, 2015 - academic.oup.com
Obesity is highly heritable. Genetic variants showing robust associations with obesity traits
have been identified through genome-wide association studies. We investigated whether a …
have been identified through genome-wide association studies. We investigated whether a …
[HTML][HTML] Genetic and epigenetic control of metabolic health
RW Schwenk, H Vogel, A Schürmann - Molecular metabolism, 2013 - Elsevier
Obesity is characterized as an excess accumulation of body fat resulting from a positive
energy balance. It is the major risk factor for type 2 diabetes (T2D). The evidence for familial …
energy balance. It is the major risk factor for type 2 diabetes (T2D). The evidence for familial …
Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmö Diet and Cancer Study
G Rukh, E Sonestedt, O Melander, B Hedblad, E Wirfält… - Genes & nutrition, 2013 - Springer
Gene–environment interactions need to be studied to better understand the obesity. We
aimed at determining whether genetic susceptibility to obesity associates with diet intake …
aimed at determining whether genetic susceptibility to obesity associates with diet intake …