Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …

Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …

Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …

The structural differences among different G-quadruplexes provide an opportunity for site-
specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex …

G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent
evidence points toward their existence in vivo and their implication in various biological …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

A promising approach for anticancer strategies is the stabilization of telomeric DNA into a G-
quadruplex structure. To explore the intrinsic stabilization of folded G-quadruplexes, we …

We report here that a tetra-substituted naphthalene-diimide derivative (MM41) has
significant in vivo anti-tumour activity against the MIA PaCa-2 pancreatic cancer xenograft …