Advances in cardiovascular research have identified oxidative stress as an important
pathophysiological pathway in the development and progression of heart failure. Oxidative …

Both oxidative stress and inflammation are enhanced in chronic heart failure. Dysfunction of
cardiac mitochondria is a hallmark of heart failure and a leading cause of oxidative stress …

Substantial evidence suggests the involvement of oxidative stress in the pathophysiology of
congestive heart failure and its antecedent conditions such as cardiac hypertrophy and …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …

Over the past several decades, investigations in humans and animal models of heart failure
(HF) have provided substantial evidence that oxidative stress is increased in HF and …

Despite advances in treatment, chronic congestive heart failure carries a poor prognosis and
remains a leading cause of cardiovascular death. Accumulating evidence suggests that …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …

Heart failure and many of the conditions that predispose to heart failure are associated with
oxidative stress. This is considered to be important in the pathophysiology of the condition …

Chronic heart failure (CHF) continues to cause substantial morbidity and mortality despite
major therapeutic advances, such as the use of angiotensin-converting enzyme (ACE) …