Human induced pluripotent stem cell (iPSC)-derived neuronal and glial cell models are
suitable to assess the effects of environmental chemicals on the developing brain. Such test …

Human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) and their
differentiated neuronal/glial derivatives have been recently considered suitable to assess in …

The human central nervous system (CNS) is very sensitive to perturbations, since it performs
sophisticated biological processes and requires cooperation from multiple neural cell types …

With the vast number of chemicals in commerce, higher throughput strategies are needed to
inform risk assessment. The field of toxicology is therefore moving away from traditional in …

This project aims to establish and characterize an in vitro model of the developing human
brain for the purpose of testing drugs and chemicals. To accurately assess risk, a model …

Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative
disease (ND) has attracted significant attentions in recent years. There is, however, a …

With increasing global health threats has come an urgent need to rapidly develop and
deploy safe and effective therapies. A common practice to fast track clinical adoption of …

Assessment of neuroactive effects of chemicals in cell-based assays remains challenging as
complex functional tissue is required for biologically relevant readouts. Recent in vitro …

Neurological disorders affect millions of people worldwide and appear to be on the rise.
Whereas the reason for this increase remains unknown, environmental factors are a …

There is a call for a paradigm shift in developmental neurotoxicity (DNT) evaluation, which
demands the implementation of faster, more cost-efficient, and human-relevant test systems …