Posttranscriptional regulation of plasminogen activator inhibitor-1 in human lung carcinoma cells in vitro

S Shetty, S Idell - … Journal of Physiology-Lung Cellular and …, 2000 - journals.physiology.org
Plasminogen activator inhibitor-1 (PAI-1), the major circulating inhibitor of urokinase
[urokinase-type plasminogen activator (uPA)], has been linked to the pathogenesis of lung …

Post-transcriptional regulation of plasminogen activator inhibitor Type–1 expression in human pleural mesothelial cells

S Shetty, T Velusamy, RS Shetty… - American journal of …, 2010 - atsjournals.org
The plasminogen activator inhibitor type–1 (PAI-1) effectively blocks the activities of free and
receptor-bound urokinase-type plasminogen activator. Incubation of cultured human pleural …

Expression of plasminogen activator inhibitors 1 and 2 in lung cancer and their role in tumor progression

C Robert, I Bolon, S Gazzeri, S Veyrenc… - Clinical cancer …, 1999 - AACR
The plasminogen activator cascade initiated by urokinase type plasminogen activator (u-PA)
is involved in extracellular matrix degradation during the tumor invasion process. The …

Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph …

H Yoshino, Y Endo, Y Watanabe, T Sasaki - British journal of cancer, 1998 - nature.com
The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and
plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung …

Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells

S Shetty, K Bdeir, DB Cines, S Idell - Journal of Biological Chemistry, 2003 - ASBMB
The plasminogen/plasmin system, urokinase-type plasminogen activator (uPA), its receptor
(uPAR), and its inhibitor (PAI-1), influence extracellular proteolysis and cell migration in lung …

Co‐expression of urokinase, urokinase receptor and PAI‐1 is necessary for optimum invasiveness of cultured lung cancer cells

G Liu, MA Shuman, RL Cohen - International journal of cancer, 1995 - Wiley Online Library
We investigated the importance of the urokinase (uPA)‐plasmin system in fostering invasion
of human lung cancer cells through artificial basement membranes composed of Matrigel …

PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity

H Furuya, Y Sasaki, R Chen, R Peres, K Hokutan… - Scientific Reports, 2022 - nature.com
The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting
as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator …

Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

K Bajou, C Maillard, M Jost, RH Lijnen, A Gils… - Oncogene, 2004 - nature.com
Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is
believed to control proteolytic activity and cell migration during angiogenesis. We report …

Cancer cells overexpress mRNA of urokinase‐type plasminogen activator, its receptor and inhibitors in human non‐small‐cell lung cancer tissue: analysis by Northern …

S Morita, A Sato, H Hayakawa, H Ihara… - … journal of cancer, 1998 - Wiley Online Library
The transcriptional localizations of urokinase‐type plasminogen activator (uPA), its receptor
(uPAR) and its inhibitors (PAI‐1 and PAI‐2), which are possibly involved in cancer …

Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2: Evidence for independent regulation

RL Cohen, J Niclas, WMF Lee, TC Wun… - Journal of Biological …, 1989 - Elsevier
Expression of plasminogen activators (PA) has been reported to be associated with invasive
tumor growth and increased metastatic ability. In order to delineate changes in PA and PA …