Simple Summary CCR4 is a chemokine receptor selectively expressed on normal T cell
subsets such as type 2 helper T cells, skin-homing T cells and regulatory T cells, and on skin …

Chemokines and chemokine receptors orchestrate cell migration and homing in the body.
Humans have at least 44 chemokines that are further classified into four subfamilies based …

The CC chemokine receptor type-4 (CCR4) belongs to the G-protein-coupled receptor
superfamily, expressed on the cell surface of T cells and its malignancy. Two CCR4 ligands …

The CC chemokine receptor 4 (CCR4) is highly expressed on type 2 helper T cells and
regulatory T (Treg) cells. Mogamulizumab, an anti-CCR4 antibody, reduces the numbers of …

Peripheral T-cell lymphoma (PTCL) is a group of lymphoid malignancy that remains difficult
to treat, as most PTCL becomes refractory or relapses, and thus there is an unmet medical …

Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5
expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by …

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of neoplastic disorders
characterized by clonally derived and skin-homing malignant T cells that express high level …

New treatments are needed for patients with cutaneous T‐cell lymphoma (CTCL),
particularly for advanced mycosis fungoides (MF) and Sezary syndrome (SS). The …

Purpose CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas
(PTCLs) and is associated with poor outcomes. Mogamulizumab (KW-0761) is a …

Introduction Chemokines and their cognate receptors play a major role in modulating
inflammatory responses. Depending on their ligand binding, chemokine receptors can …