[HTML][HTML] Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies
F Mazzarotto, MH Hawley, M Beltrami, L Beekman… - Genetics in …, 2021 - Elsevier
Purpose To characterize the genetic architecture of left ventricular noncompaction (LVNC)
and investigate the extent to which it may represent a distinct pathology or a secondary …
and investigate the extent to which it may represent a distinct pathology or a secondary …
Novel genetic triggers and genotype–phenotype correlations in patients with left ventricular noncompaction
K Miszalski-Jamka, JL Jefferies, W Mazur… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) is a genetically and phenotypically
heterogeneous disease and, although increasingly recognized in clinical practice, there is a …
heterogeneous disease and, although increasingly recognized in clinical practice, there is a …
A wide and specific spectrum of genetic variants and genotype–phenotype correlations revealed by next‐generation sequencing in patients with left ventricular …
C Wang, Y Hata, K Hirono, A Takasaki… - Journal of the …, 2017 - Am Heart Assoc
Background Left ventricular noncompaction (LVNC) has since been classified as a primary
genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present …
genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present …
Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity
Left ventricular non‐compaction (LVNC) is a cardiomyopathy that may be of genetic origin;
however, few data are available about the yield of mutation, the spectrum of genes and …
however, few data are available about the yield of mutation, the spectrum of genes and …
Genetic basis of left ventricular noncompaction
P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …
Genetic architecture of left ventricular noncompaction in adults
SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …
Loss of Function Mutations in NNT Are Associated With Left Ventricular Noncompaction
MN Bainbridge, EE Davis, WY Choi… - Circulation …, 2015 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) is an autosomal-dominant, genetically
heterogeneous cardiomyopathy with variable severity, which may co-occur with cardiac …
heterogeneous cardiomyopathy with variable severity, which may co-occur with cardiac …
Genotype‐positive status is associated with poor prognoses in patients with left ventricular noncompaction cardiomyopathy
S Li, C Zhang, N Liu, H Bai, C Hou, J Wang… - Journal of the …, 2018 - Am Heart Assoc
Background Left ventricular noncompaction cardiomyopathy (LVNC) is a genetically and
phenotypically heterogeneous disease. This study aims to investigate the genetic basis and …
phenotypically heterogeneous disease. This study aims to investigate the genetic basis and …
The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy
YM Hoedemaekers, K Caliskan, M Michels… - Circulation …, 2010 - Am Heart Assoc
Background—Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …
Left ventricular noncompaction: a distinct cardiomyopathy or a trait shared by different cardiac diseases?
E Arbustini, F Weidemann, JL Hall - Journal of the American College of …, 2014 - jacc.org
Whether left ventricular noncompaction (LVNC) is a distinct cardiomyopathy or a
morphologic trait shared by different cardiomyopathies remains controversial. Current …
morphologic trait shared by different cardiomyopathies remains controversial. Current …
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