The generation of effective adaptive T-cell memory is a cardinal feature of the adaptive
immune system. The establishment of protective T-cell immunity requires the differentiation …

The development of immune memory mediated by T lymphocytes is central to durable, long‐
lasting protective immunity. A key issue in the field is how to direct the generation and …

Highlights•The effector and memory CD8+ T cell populations exhibit significant
heterogeneity.•Effector and memory T cell subsets exist in 'states' and retain some degree of …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

The ability of the immune system to 'remember'a previous encounter with antigen is the
hallmark of the adaptive immune response. The signals required for CD4+ memory T cell …

Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …

After antigenic stimulation in the context of" danger signals," naive T cells embark on a
programmed, intense expansion phase to counteract the rapid proliferation of pathogens …

Immunologic memory is the adaptive immune system's powerful ability to remember a
previous antigen encounter and react with accelerated vigor upon antigen re-exposure. It …

CD8+ T cell immunological memory of past antigen exposure can confer long-lived
protection against infections or tumors. The fact that CD8+ memory T cells can have features …

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …