Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models

H Li, X Yu, C Li, L Ma, Z Zhao, S Guan, L Wang - Food & Function, 2021 - pubs.rsc.org
Caffeic acid (CA), a derivative of cinnamic acid, exists in various vegetables and fruits.
Natural compounds as beneficial antioxidants play an important role in the research of …

[HTML][HTML] Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans

D Liu, X Zeng, L Li, ZL Ou - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Carnitine is required for transporting fatty acids into the mitochondria for β-oxidation.
Carnitine has been used as an energy supplement but the roles in improving health and …

[HTML][HTML] Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology

G Tasseva, HD Bai, M Davidescu, A Haromy… - Journal of Biological …, 2013 - ASBMB
Mitochondrial dysfunction is implicated in neurodegenerative, cardiovascular, and metabolic
disorders, but the role of phospholipids, particularly the nonbilayer-forming lipid …

Detrimental effects of fructose on mitochondria in mouse motor neurons and on C. elegans healthspan

D Lodha, S Rajasekaran, T Jayavelu… - Nutritional …, 2022 - Taylor & Francis
Background: Fructose-common sweetener, consumed in large quantities, is now known to
be associated with various metabolic diseases. Recent reports suggest fructose's …

[HTML][HTML] The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia

MJ Lee, SH Park, JH Han, YK Hong, S Hwang, S Lee… - Molecules and …, 2011 - Elsevier
Hempseed is rich in polyunsaturated fatty acids (PUFAs), which have potential as
therapeutic compounds for the treatment of neurodegenerative and cardiovascular disease …

Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans

B Dilberger, S Baumanns, F Schmitt… - Oxidative medicine …, 2019 - Wiley Online Library
Introduction. Mitochondria supply cellular energy and are key regulators of intrinsic cell
death and consequently affect longevity. The nematode Caenorhabditis elegans is …

Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans

BL Graf, S Kamat, KY Cheong, S Komarnytsky… - Journal of Functional …, 2017 - Elsevier
Abstract Quinoa (Chenopodium quinoa Willd.) phytochemicals have exhibited metabolic
benefit in mammals, though their effects on aging and mechanisms of action remain …

Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels

K Takahashi, S Yanai, K Shimokado, A Ishigami - Nutrition, 2017 - Elsevier
Objective Coffee, one of the world's most consumed beverages, has many benefits. Some
studies have reported the effects of coffee on aging. The aim of this study was to investigate …

Protection of brain and pancreas from high-fat diet: Effects of catechin and caffeine

K Unno, H Yamamoto, K Maeda, F Takabayashi… - Physiology & …, 2009 - Elsevier
To investigate the effect of a high-fat diet on brain and pancreas functions, we used SAMP10
mice that have characteristics of brain atrophy and cognitive dysfunction with aging …

Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans

LI Grad, LC Sayles, BD Lemire - Proceedings of the …, 2005 - National Acad Sciences
Mitochondrial dysfunction, with an estimated incidence of 1 in 5,000 births, is associated
with a wide variety of multisystem degenerative diseases. Among the most prevalent forms …