The concept of “magic bullets”, ie, drugs able to selectively act on target cells, formulated by
Paul Ehrlich more than one century ago, gave rise to the idea of immunotargeting, one of the …

After more than 50 years of research, studies on the structure and biological activities of
ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or
an antibody fragment. Conjugation can be obtained by chemical or genetic engineering …

Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected
organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby …

Immunotoxins are anticancer agents with at least two functional components, one of which
binds to a tumor-specific, internalizing cell-surface antigen and one that confers cellular …

Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical
development for a variety of malignancies. They consist of an antibody-based targeting …

Immunotoxins constitute a new modality for the treatment of cancer, since they target cells
displaying specific surface-receptors or antigens. Immunotoxins contain a ligand such as a …

Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused
to a targeting moiety. Various toxic agents from different sources are used in immunotoxin …

DESTRUCTION OF ONE SPECIFIC cell population within an organism without harmful
effects on the other cell populations within the same organism is the challenge of modern …