Ecotoxicological perspectives of sex determination

BA Mizoguchi, N Valenzuela - Sexual Development, 2016 - karger.com
Sex determination or the commitment of the embryo to its sexual fate is a fundamental
developmental process with paramount consequences in ecology and evolution. This …

Embryonic PCB exposure alters phenotypic, genetic, and epigenetic profiles in turtle sex determination, a biomarker of environmental contamination

Y Matsumoto, B Hannigan, D Crews - Endocrinology, 2014 - academic.oup.com
In species with temperature-dependent sex determination, embryonic gonadal differentiation
can be modified by exposure to exogenous chemicals such as environmental contaminants …

The role of estrogen in turtle sex determination and the effect of PCBs.

D Crews, JM Bergeron… - Environmental health …, 1995 - ehp.niehs.nih.gov
In the current model of vertebrate sex determination and sexual differentiation, gonadal sex
is fixed at fertilization by specific chromosomes, a process known as genotypic sex …

Thermal response of epigenetic genes informs turtle sex determination with and without sex chromosomes

S Radhakrishnan, R Literman, JL Neuwald… - Sexual …, 2018 - karger.com
Vertebrate sexual fate can be established by environmental cues (eg, temperature-
dependent sex determination, TSD) or by genetic content (genotypic sex determination …

Exogenous application of estradiol to eggs unexpectedly induces male development in two turtle species with temperature-dependent sex determination

DA Warner, E Addis, W Du, T Wibbels… - General and comparative …, 2014 - Elsevier
Steroid hormones affect sex determination in a variety of vertebrates. The feminizing effects
of exposure to estradiol and the masculinizing effects of aromatase inhibition during …

Gonadal differentiation in reptiles exhibiting environmental sex determination

S Kohno, BB Parrott, R Yatsu, S Miyagawa… - Sexual …, 2014 - karger.com
As temperature-dependent sex determination (TSD) and homozygote or heterozygote
genetic sex determination (GSD) exist in multiple reptilian taxa, they represent sex …

Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)

CM Jandegian, SL Deem, RK Bhandari… - General and …, 2015 - Elsevier
Environmental chemicals can disrupt endocrine signaling and adversely impact sexual
differentiation in wildlife. Bisphenol A (BPA) is an estrogenic chemical commonly found in a …

Steroid signaling and temperature-dependent sex determination—Reviewing the evidence for early action of estrogen during ovarian determination in turtles

M Ramsey, D Crews - Seminars in cell & developmental biology, 2009 - Elsevier
The developmental processes underlying gonadal differentiation are conserved across
vertebrates, but the triggers initiating these trajectories are extremely variable. The red …

Reptiles as models of contaminant-induced endocrine disruption

DA Crain, LJ Guillette Jr - Animal reproduction science, 1998 - Elsevier
Historically, reptiles have been used as bioindicators of environmental contaminants and,
currently, reptiles have the potential to elucidate the mechanisms of a newly described …

Temperature‐dependent sex determination in reptiles: proximate mechanisms, ultimate outcomes, and practical applications

D Crews, JM Bergeron, JJ Bull, D Flores… - Developmental …, 1994 - Wiley Online Library
In many egg‐laying reptiles, the incubation temperature of the egg determines the sex of the
offspring, a process known as temperature‐dependent sex determination (TSD). In TSD sex …