Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.
V Raymond, JA Atwater, IM Verma - Oncogene research, 1989 - europepmc.org
AU-sequence motifs present in the 3'untranslated region (UTR) of many rapidly inducible
messenger RNAs have been proposed to mediate their selective degradation. We have …
messenger RNAs have been proposed to mediate their selective degradation. We have …
[PDF][PDF] Requirements for c-fos mRNA down regulation in growth stimulated
The fos proto-oncogene is rapidly and transiently expressed in resting cells exposed to
growth stimulation. This gene is down-regulated at least at two levels: tran-scriptional …
growth stimulation. This gene is down-regulated at least at two levels: tran-scriptional …
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.
AB Shyu, ME Greenberg, JG Belasco - Genes & development, 1989 - genesdev.cshlp.org
Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …
expression. Experiments were performed to investigate the cellular mechanisms responsible …
c-fos mRNA instability determinants present within both the coding and the 3'non coding region link the degradation of this mRNA to its translation.
JL Veyrune, S Carillo, A Vié, JM Blanchard - Oncogene, 1995 - europepmc.org
The instability of oncogenic mRNA such as c-fos mRNA is controlled in cis by sequences
present in both the coding and the 3'untranslated regions (3'UTR). The latter contains AU …
present in both the coding and the 3'untranslated regions (3'UTR). The latter contains AU …
[HTML][HTML] Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.
SC Schiavi, CL Wellington, AB Shyu, CY Chen… - Journal of biological …, 1994 - Elsevier
The c-fos proto-oncogene transcript is one of the most labile mammalian mRNAs known.
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c- fos recombinants
N Roy, G Laflamme, V Raymond - Nucleic acids research, 1992 - academic.oup.com
One major determinant of rapid mRNA decay is the presence of AU-rich sequences located
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
Deadenylylation: a mechanism controlling c-fos mRNA decay
ME Greenberg, AB Shyu, JG Belasco - Enzyme, 1990 - karger.com
The c-fos proto-oncogene mRNA is extremely labile and is rapidly degraded within minutes
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos …
WMF Lee, C Lin, T Curran - Molecular and cellular biology, 1988 - Taylor & Francis
The requirements for activation of the transformation potential of the human c-fos proto-
oncogene were investigated. Recombinant plasmids containing the Moloney murine …
oncogene were investigated. Recombinant plasmids containing the Moloney murine …
U-Rich Sequence-Binding Proteins (URBPs) Interacting with a 20-Nucleotide U-Rich Sequence in the 3′ Untranslated Region of c-fos mRNA May Be Involved in the First Step …
Y You, CYA Chen, AB Shyu - Molecular and cellular biology, 1992 - Taylor & Francis
Rapid decay of the c-fos transcript plays a critical role in controlling transforming potential of
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
Posttranscriptional regulation of c-fos mRNA expression
HJ Rahmsdorf, A Schönthal, P Angel… - Nucleic acids …, 1987 - academic.oup.com
The transient induction of c-fos mRNA and protein suggests that regulation occurs not only
by transcriptional activation but also at the level of turnover of the gene product. Here we …
by transcriptional activation but also at the level of turnover of the gene product. Here we …