G protein-coupled inwardly rectifying potassium (GIRK) channels can be activated or
inhibited by different classes of receptors, suggesting a role for G proteins in determining …

G-protein-coupled inwardly rectifying K+(GIRK; Kir3. x) channels are the primary effectors of
numerous G-protein-coupled receptors. GIRK channels decrease cellular excitability by …

G protein-sensitive inwardly rectifying potassium (GIRK) channels are activated through
direct interactions of their cytoplasmic N-and C-terminal domains with the βγ subunits of G …

We have previously shown that direct binding of the βγ subunit of G protein (Gβγ) to both the
N-terminal domain and the C-terminal domain of a cloned G protein-gated inward-rectifying …

Gβγ subunits interact directly and activateG protein-gated Inwardly RectifyingK+(GIRK)
channels. Little is known about the identity of functionally important interactions between …

Neuronal G protein-coupled inwardly-rectifying potassium channels (GIRKs, Kir3. x) can be
activated or inhibited by distinct classes of receptors (Gαi/o and Gαq/11-coupled …

G protein coupled inwardly rectifying K+ channels (GIRK/Kir3. x) are mainly activated by a
direct interaction with Gβγ subunits, released upon the activation of inhibitory …

Key points The G‐protein coupled inwardly rectifying potassium (GIRK) channel is an
important mediator of neurotransmission via Gβγ subunit of the heterotrimeric Gi/o protein …

The activity of G protein‐activated inwardly rectifying K+ channels (GIRK or Kir3) is important
for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although Gβγ …

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gβγ. The
binding sites of Gβγ in the ubiquitous GIRK1 (Kir3. 1) subunit have not been unequivocally …