Immune regulation of metabolic homeostasis in health and disease

JR Brestoff, D Artis - Cell, 2015 - cell.com
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …

Innate immune control of adipose tissue homeostasis

H Kane, L Lynch - Trends in immunology, 2019 - cell.com
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis.
Recently, the immune system has been implicated in the regulation of adipose tissue …

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

K Man, A Kallies, A Vasanthakumar - Cellular & molecular immunology, 2022 - nature.com
Glucose is a vital source of energy for all mammals. The balance between glucose uptake,
metabolism and storage determines the energy status of an individual, and perturbations in …

[HTML][HTML] Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity

JY Huh, YJ Park, M Ham, JB Kim - Molecules and cells, 2014 - Elsevier
Recent findings, notably on adipokines and adipose tissue inflammation, have revised the
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …

Interplay between the immune system and adipose tissue in obesity

MA Exley, L Hand, D O'Shea… - Journal of …, 2014 - joe.bioscientifica.com
Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT)
inflammation emerging as a key underlying pathology. Alongside its major role in energy …

Adipose tissue immunomodulation: a novel therapeutic approach in cardiovascular and metabolic diseases

I AlZaim, SH Hammoud, H Al-Koussa… - Frontiers in …, 2020 - frontiersin.org
Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

Adipose tissue-resident immune cells: key players in immunometabolism

HS Schipper, B Prakken, E Kalkhoven… - Trends in Endocrinology & …, 2012 - cell.com
Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT
exerts metabolic control through various immunological mechanisms that instigated a new …

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

S Winer, DA Winer - Immunology and cell biology, 2012 - Wiley Online Library
Over the past decade, chronic inflammation in visceral adipose tissue (VAT) has gained
acceptance as a lead promoter of insulin resistance in obesity. A great deal of evidence has …

Adipocytes, innate immunity and obesity: A mini-review

AM Blaszczak, A Jalilvand, WA Hsueh - Frontiers in immunology, 2021 - frontiersin.org
The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications
is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the …

Immune regulation in obesity-associated adipose inflammation

JM Han, MK Levings - The Journal of Immunology, 2013 - journals.aai.org
Adipose tissue inflammation is often a consequence of obesity and is characterized by
infiltration and activation of immune cells that overproduce cytokines and chemokines. This …