Camptothecin (CPT) is a potent antitumor alkaloid isolated in 1966 by ME Wall. Clinical use
of camptothecin in cancer therapy, however, was limited by its poor water solubility …

A robust, practical synthesis of (20S)‐10‐(3‐aminopropyloxy)‐7‐ethylcamptothecin (T‐2513,
5), which is a water‐soluble analogue of camptothecin, has been developed. The key step in …

New water soluble camptothecin derivatives with excellent antitumor activity have been
designed and synthesized. The synthetic approach includes an efficient route to 7 …

Synthesis of 9‐Allyl‐10‐hydroxycamptothecin via Suzuki Reaction - Luo - 2014 - Journal of
Heterocyclic Chemistry - Wiley Online Library Skip to Article Content Skip to Article Information …

Camptothecin is an important antitumor product from Camptotheca acuminata, however, the
disadvantages, such as poor solubility, toxicity and metabolic inactivation, block its …

In an effort to decrease the toxicity and improve the stability of labile lactone ring of
camptothecin, nitrogenous heterocyclic aromatic groups were introduced into 20-position of …

A series of novel 10-substituted camptothecin analogs (3–10) with a carbamate linker were
synthesized, and their biological activities were evaluated. The amino acid-linked carbamate …

This study presents synthetic studies on camptothecin, a potent antitumor agent in order to
improve its stability and solubility without reducing its activity. The study consists of the …

A series of 10-arylcamptothecin derivatives was designed and synthesized. The key step of
the synthesis was achieved by employing Suzuki cross-coupling chemistry. All of the new …

A novel camptothecin analogue, 9-methyl-10-hydroxycamptothecin (4), was unexpectedly
synthesized from 10-hydroxycamptothecin in two steps. The key step included an efficient …