Abstract A variety of 5‐aryl‐(20S)‐camptothecin derivatives were synthesized by the
reaction of 5‐hydroxy‐(20S)‐camptothecin with aromatic hydrocarbons under Friedel‐Craft …

Camptothecin, a monoterpene indole alkaloid, first isolated from the Chinese tree
Camptotheca acuminata Decaisne in 1957. Camptothecin has been found not only in C …

A series of novel substituted uracil-1′(N)-acetic acid esters (6–20) of camptothecins (CPTs)
were synthesized by the acylation method. These new compounds were evaluated for …

Camptothecin is an alkaloid with a novel ring system. As will be discussed later, it has been
reported to possess antileukemic and antitumor activities in animals and humans. In 1966 …

SN-38 (7-ethyl-10-hydroxycamptothecin) is an active metabolite derived from the semi-
synthetic compound camptothecin (CPT) named Irinotecan (CPT-11). The antitumor activity …

Camptothecin (If, isolated by MC Wani and his coworkers1 from the bark of Camptotheta
acuminta, has shown tremendous potential as an antitumor and antileukemic agent.'Off late …

Based on a new semisynthetic route, a series of phosphotriester 7-alkyl-homocamptothecin
derivatives are designed and synthesized. Cytotoxic activity assays show that compounds …

Camptothecin (CPT, I), a unique pentacyclic quinoline alkaloid originally isolated from a
native tree of Tibet and China called Camptotheca acuminata in latin and Xi Shu in Chinese …

A series of novel 9-substituted camptothecins derived from 9-formylcamptothecin were
synthesized. The aldehyde was obtained from 10-hydroxycamptothecin or, better, by total …