The role of cells of the mononuclear phagocyte system (MPS), which includes the Kupffer
cells in the liver; alveolar, splenic, lymph node, and bone marrow macrophages; tissue …

As the role of monocytes and macrophages in a range of diseases is better understood,
strategies to target these cell types are of growing importance both scientifically and …

Macrophages are particularly effective in dealing with microorganisms that cause chronic
and intracellular infectious diseases and with organisms that have eluded killing by …

In recent years, a considerable effort has been made to promote the use of liposomes as
potential carriers for systemically administered chemotherapeutic agents. It is our belief that …

The potential for cellular diversity of neoplastic tissue has been recognized for over a
century, ever since the initial pathological descriptions of “pleomorphism” and its …

Many investigators have proposed that liposomes be utilized as carriers to deliver drugs.
One perceived difficulty in this approach has been that liposomes are cleared rapidly by …

Heterogeneous functions of macrophages in human immune systems have renewed interest
in targeting of drugs to these cells. Various carrier systems have emerged to deliver drugs to …

Publisher Summary This chapter discusses the interaction of cancer chemotherapy agents
with mononuclear phagocytes. Cells of the monocyte-macrophage lineage represent a …

The central role played by cells of the mononuclear phagocyte system (MPS) such as
alveolar macrophages, hepatic Kupffer cells, splenic and lymph node macrophages, tissue …

It is well established that after intravenous injection large-size liposomes are rapidly cleared
from the blood and taken up by cells belonging to the reticulo-endothelial system (RES) …