Secondary lymphoid organs like lymph nodes (LN s) are the main inductive sites for
adaptive immune responses. Lymphocytes are constantly entering LN s, scanning the …

Lymph nodes (LN s) are secondary immune organs dispersed throughout the body. They
are primarily composed of lymphocytes,“transient passengers” that are only present for a few …

The continuous migration of immune cells between lymphoid and nonlymphoid organs is a
key feature of the immune system, facilitating the distribution of effector cells within nearly all …

Lymph nodes (LNs) are the organs where innate immune responses lead to acquired
immunity, where some of our most devastating pathogens evade immunity, and where …

Knowledge of lymphocyte migration has become a major issue in our understanding of
acquired immunity. The selective migration of naïve, effector, memory and regulatory T-cells …

The development of an adaptive immune response requires well coordinated mechanisms
in order to navigate circulating immune cells through peripheral tissues and into secondary …

The lymphoid tissues are characterized by a complex organized architecture that is
supported by a network of stromal cells. These stromal cells play many important roles in …

This review describes recent breakthroughs in our understanding of the roles played by
chemokines in lymphocyte trafficking. These include the first demonstration that chemokines …

Migration of antigen-presenting dendritic cells (DCs) through lymphatics to draining lymph
nodes (LNs) represents a key step in the initiation of an adaptive immune response. In this …

Chemokines are a large family of small, generally secreted polypeptides which guide
lymphocyte movement throughout the body by controlling integrin avidity and inducing …