The K+ channel inward rectifier subunits form a channel similar to neuronal G protein‐gated K+ channel
BM Velimirovic, EA Gordon, NF Lim, B Navarro… - FEBS …, 1996 - Wiley Online Library
G protein‐activated inwardly rectifying K+ channel subunits GIRK1 (Kir 3.1), GIRK2 (Kir 3.2),
and CIR (Kir 3.4) were expressed individually or in combination in Xenopus oocytes and …
and CIR (Kir 3.4) were expressed individually or in combination in Xenopus oocytes and …
Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain
E Dißmann, E Wischmeyer, A Spauschus… - Biochemical and …, 1996 - Elsevier
We have cloned by homology screening from a rat brain cDNA library a GIRK3-type (Kir 3.3)
inwardly rectifying K+ channel subunit with high structural similarity to other subfamily …
inwardly rectifying K+ channel subunit with high structural similarity to other subfamily …
Functional Expression and Characterization of G-protein-gated Inwardly Rectifying K+ Channels Containing GIRK3
TM Jelacic, SM Sims, DE Clapham - The Journal of membrane biology, 1999 - Springer
The G-protein-gated i nwardly r ectifying K+(GIRK) family of ion channels form functional
Gβγ-sensitive channels as heteromultimers of GIRK1 and either the GIRK2 or GIRK4 …
Gβγ-sensitive channels as heteromultimers of GIRK1 and either the GIRK2 or GIRK4 …
Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activity
KW Chan, JL Sui, M Vivaudou, DE Logothetis - Journal of Biological …, 1997 - ASBMB
Heterologous coexpression of recombinant, G protein-gated, inwardly rectifying K+(GIRK)
channel subunits has yielded large currents, severalfold greater than those obtained from …
channel subunits has yielded large currents, severalfold greater than those obtained from …
Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels
Four cDNA-encoding G-activated inwardly rectifying K+ channels have been cloned recently
(Kubo, Y., Reuveny, E., Slesinger, PA, Jan, YN, and Jan, LY (1993) Nature 364, 802-806; …
(Kubo, Y., Reuveny, E., Slesinger, PA, Jan, YN, and Jan, LY (1993) Nature 364, 802-806; …
Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3
TM Jelacic, ME Kennedy, K Wickman… - Journal of Biological …, 2000 - ASBMB
G-protein-gated inwardly rectifying K+(GIRK) channels are widely expressed in the brain
and are activated by at least eight different neurotransmitters. As K+ channels, they drive the …
and are activated by at least eight different neurotransmitters. As K+ channels, they drive the …
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers
The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3
cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK …
cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK …
Cloning provides evidence for a family of inward rectifier and G‐protein coupled K+ channels in the brain
MbIRK3, mbGIRK2 and mbGIRK3 K+ channels cDNAs have been cloned from adult mouse
brain. These eDNAs encode polypeptides of 445, 414 and 376 amino acids, respectively …
brain. These eDNAs encode polypeptides of 445, 414 and 376 amino acids, respectively …
[HTML][HTML] Importance of the G protein γ subunit in activating G protein-coupled inward rectifier K+ channels
T Kawano, L Chen, SY Watanabe, J Yamauchi… - FEBS letters, 1999 - Elsevier
The G protein-coupled inward rectifier K+ channel (GIRK) is activated by direct interaction
with the heterotrimeric GTP-binding protein βγ subunits (Gβγ). However, the precise role of …
with the heterotrimeric GTP-binding protein βγ subunits (Gβγ). However, the precise role of …
Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.
Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …