Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor …

Free-radicals (Oxygen and Nitrogen species) are formed in mitochondria during the
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …

Both physiological and pathological aging processes induce brain alterations especially
affecting the speed of processing, working memory, conceptual reasoning and executive …

Mitochondrial dysfunction plausibly underlies the aging-associated brain degeneration.
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival. Oxidative stress …

Aging and neurodegenerative diseases share oxidative stress cell damage and depletion of
endogenous antioxidants as mechanisms of injury, phenomena that are occurring at …

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Oxidative stress plays a crucial role in Alzheimer's disease (AD) from its prodromal stage of
mild cognitive impairment. There is an interplay between oxidative stress and the amyloid β …

Mitochondrial diseases (MDs) may result from mutations affecting nuclear or mitochondrial
genes, encoding mitochondrial proteins, or non-protein-coding mitochondrial RNA. Despite …

Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

Although the etiology for many neurodegenerative diseases is unknown, the common
findings of mitochondrial defects and oxidative damage posit these events as contributing …