Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social,
political and economic concern. Despite significant investment in multiple traditional …

Aging is defined as the functional loss of tissues and organs over time. This is a biological,
irreversible, progressive, and universal process that results from genetic and environmental …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …

Hyperphysiological burden of free radicals causes imbalance in homeostatic phenomena
between oxidants and antioxidants in the body. This imbalance leads to oxidative stress that …

J. Neurochem.(2010) 114, 933–945. Abstract Despite the increasing knowledge of
Alzheimer's disease (AD) management with novel pharmacologic agents, most of them are …

Various neurodegenerative disorders and syndromes are associated with oxidative stress.
The deleterious consequences of excessive oxidations and the pathophysiological role of …

Abstract “Modern” medicine and pharmacology require an effective medical drug with a
single compound for a specific disease. This seams very scientific but usually has …

Multiple sclerosis (MS) is a chronic, multifactorial disease of the central nervous system
(CNS), typified by repetitive relapses and/or progression. The conventional treatment …

Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …