The emerging problem of antibiotic resistance, especially among Gram-negative bacteria
(GNB), has become a serious threat to global public health. Very few new antibacterial …

The spread of multidrug-resistant bacteria is an ever-growing concern, particularly among
Gram-negative bacteria because of their intrinsic resistance and how quickly they acquire …

Background: Infections caused by multi-drug resistant (MDR) Gram-negative bacteria
represent an ever-growing area of unmet medical need. To address this need, it is …

Introduction: Infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB)
are associated with significant mortality and costs. New drugs in development to combat …

Infections caused by antibiotic-resistant bacteria, especially the “ESKAPE” pathogens,
continue to increase in frequency and cause significant morbidity and mortality. New …

Introduction: The constantly increasing spread of severe infections due to multidrug-resistant
(MDR) Gram-negative bacteria (GNB) is a critical threat to the global medical community …

Abstract Background Antibiotic resistance in Gram-negative resistance has developed
without a commensurate response in the successful development of antibiotic agents …

Background The discovery of antibiotics several decades ago was a defining moment in
history. They were used to treat previously incurable diseases and save many lives …

Introduction: The emergence and diffusion of multidrug-resistant Gram-negative bacteria
(MDR-GNB) is an unprecedented threat, with prevalences as high as 10–50% being …

Highlights•Carbapenem-resistant Gram-negative pathogens are a priority for R&D,
according to WHO.•Increasing need for new therapies against Klebsiella, Pseudomonas and …