Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal
death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and …

Alzheimer disease is a common age-related neurodegenerative disease characterized
pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and …

Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress
including in those brain areas directly involved in the neurodegenerative process of …

Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically
by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

Accumulation of oxidative damage is a common feature of neurodegeneration that, together
with mitochondrial dysfunction, point to the fact that reactive oxygen species are major …

In Alzheimer's disease (AD) brain oxidative stress is observed indexed by several markers,
among which are protein carbonyls and 3-nitrotyrosine, markers for protein oxidation. We …

Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly
population with complex etiology. Many hypotheses have been proposed to explain different …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number
of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a …