Alzheimer's disease (AD) is the most common form of neurodegenerative disease
associated with dementia in the elderly. Although the initiating events are still unknown, it is …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. A number of
hypotheses have been proposed to explain AD pathogenesis. One such hypothesis …

One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative
stress hypothesis. The amyloid β-peptide (Aβ), a hallmark in the pathogenesis of AD and the …

As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Background: Neurodegeneration is a condition in which progressive loss of function and
structure of neurons occurs. Several lines of evidence suggest that oxidative stress has a …

Background Several studies suggest that pathological changes in Alzheimer's disease (AD)
brain begin around 10–20 years before the onset of cognitive impairment. Biomarkers that …

Age-associated neurodegenerative disorders are becoming more prevalent as the mean
age of the population increases in the United States over the next few decades. Both normal …

The brain is susceptible to oxidative stress, which is associated with age-related brain
dysfunction, because of its high content of peroxidizable unsaturated fatty acids, high …

The brain and nervous system are prone to oxidative stress, and are inadequately equipped
with antioxidant defense systems to prevent 'ongoing'oxidative damage, let alone the extra …

Background: Carbonylation is an irreversible oxidative modification of proteins that has been
linked to various conditions of oxidative stress, aging, physiological disorders, and disease …