The intestinal epithelium is characterized by rapid cellular turnover with continuous
proliferation of multipotential stem cells within Lieberkuhn's crypts, cellular migration along …

The function and structure of the mammalian epithelial cell layer is maintained by distinct
intercellular adhesion complexes including adherens junctions (AJs), tight junctions, and …

Background E-cadherin is a major component of adherens junctions. Impaired expression of
E-cadherin in the small intestine and colon has been linked to a disturbed intestinal …

The intestinal epithelial layer forms an important barrier that protects underlying tissues from
bacteria within the gut lumen. This single monolayer is comprised of epithelial cells that are …

Epithelial-cadherin (E-cadherin) is a master organizer of the epithelial phenotype. Its
function is regulated in part by p120-catenin (referred to herein as p120), a cytoplasmic …

The E-cadherin–catenin complex is important for the maintenance of epithelial architecture.
We studied its expression in Crohn disease, ulcerative colitis, acute ileitis, and controls …

The epithelial monolayer of the intestine is a selective barrier permitting nutrient and
electrolyte absorption yet acting to protect the underlying tissue compartments and cellular …

E-cadherin is the core component of epithelial adherens junctions, essential for tissue
development, differentiation, and maintenance. It is also fundamental for tissue barrier …

Anoikis, ie apoptosis induced by detachment from the extracellular matrix, is thought to be
involved in the shedding of enterocytes at the tip of intestinal villi. Mechanisms controlling …

Continuous cell renewal in the intestinal mucosa occurs without disrupting the integrity of the
epithelial layer. Despite the restrictions imposed by strong cell-to-cell adhesions, epithelial …