The mucosal immune system: master regulator of bidirectional gut–brain communications

N Powell, MM Walker, NJ Talley - Nature reviews Gastroenterology & …, 2017 - nature.com
Communication between the brain and gut is not one-way, but a bidirectional highway
whereby reciprocal signals between the two organ systems are exchanged to coordinate …

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions

C Tait, GS Sayuk - European Journal of Internal Medicine, 2021 - Elsevier
Functional gastrointestinal disorders (FGIDs), characterized by chronic abdominal
complaints without a structural or biochemical cause, are common diseases that are …

[HTML][HTML] Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

JR Kelly, PJ Kennedy, JF Cryan, TG Dinan… - Frontiers in cellular …, 2015 - frontiersin.org
The emerging links between our gut microbiome and the central nervous system are
regarded as a paradigm shift in neuroscience with possible implications for not only …

[HTML][HTML] Role of the gut–brain axis in energy and glucose metabolism

HR Wachsmuth, SN Weninger, FA Duca - Experimental & molecular …, 2022 - nature.com
The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Boundaries and integration between microbiota, the nervous system, and immunity

AJ Macpherson, V Pachnis, M Prinz - Immunity, 2023 - cell.com
The enteric nervous system is largely autonomous, and the central nervous system is
compartmentalized behind the blood-brain barrier. Yet the intestinal microbiota shapes gut …

[HTML][HTML] Microbiome—the missing link in the gut-brain axis: focus on its role in gastrointestinal and mental health

K Skonieczna-Żydecka, W Marlicz, A Misera… - Journal of clinical …, 2018 - mdpi.com
The central nervous system (CNS) and the human gastrointestinal (GI) tract communicate
through the gut-brain axis (GBA). Such communication is bi-directional and involves …

[HTML][HTML] Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians

E Sinagra, E Utzeri, GC Morreale, C Fabbri… - World journal of …, 2020 - ncbi.nlm.nih.gov
Despite the bi-directional interaction between gut microbiota and the brain not being fully
understood, there is increasing evidence arising from animal and human studies that show …

Neurotransmitter modulation by the gut microbiota

P Strandwitz - Brain research, 2018 - Elsevier
The gut microbiota–the trillions of bacteria that reside within the gastrointestinal tract–has
been found to not only be an essential component immune and metabolic health, but also …

[HTML][HTML] The microbiota-immune axis as a central mediator of gut-brain communication

TC Fung - Neurobiology of disease, 2020 - Elsevier
Intestinal inflammatory disorders are associated with neurophysiological and behavioral
symptoms. Conversely, many disorders of the central nervous system (CNS) are …

Brain–gut microbiome interactions and functional bowel disorders

EA Mayer, T Savidge, RJ Shulman - Gastroenterology, 2014 - Elsevier
Alterations in the bidirectional interactions between the intestine and the nervous system
have important roles in the pathogenesis of irritable bowel syndrome (IBS). A body of largely …