At the crossroads of fertility and metabolism: The importance of AMPK-dependent signaling in female infertility associated with hyperandrogenism

P Froment, I Plotton, C Giulivi, S Fabre… - Human …, 2022 - academic.oup.com
STUDY QUESTION What biological processes are linked to the signaling of the energy
sensor 5′-AMP-activated protein kinase (AMPK) in mouse and human granulosa cells …

Roles of AMP-activated protein kinase (AMPK) in mammalian reproduction

W Yang, L Wang, F Wang, S Yuan - Frontiers in Cell and …, 2020 - frontiersin.org
Reproduction is an energy demanding function and only take place in case of sufficient
available energy status in mammals. Metabolic diseases such as anorexia nervosa are …

AMPK: a master energy regulator for gonadal function

MJ Bertoldo, M Faure, J Dupont… - Frontiers in neuroscience, 2015 - frontiersin.org
From C. elegans to mammals (including humans), nutrition and energy metabolism
significantly influence reproduction. At the cellular level, some detectors of energy status …

Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology

P Tartarin, E Guibert, A Touré, C Ouiste… - …, 2012 - academic.oup.com
AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, is
present in metabolic tissues (muscle and liver) and has been identified as a modulator of the …

Role of AMPK in mammals reproduction: Specific controls and whole-body energy sensing

TMD Nguyen - Comptes Rendus Biologies, 2019 - Elsevier
AMP-activated protein kinase (AMPK) is a key enzyme involved in linking the energy
sensing to metabolic pathways. As such, it plays a central role at the whole-body level to …

Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells

A Hirsch, D Hahn, P Kempná, G Hofer, PE Mullis… - PLoS …, 2012 - journals.plos.org
Regulation of human androgen biosynthesis is poorly understood. However, detailed
knowledge is needed to eventually solve disorders with androgen dysbalance. We showed …

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality

MJ Bertoldo, E Guibert, M Faure, F Guillou… - Molecular and Cellular …, 2016 - Elsevier
The AMP-activated protein kinase (AMPK) is an important regulator of cellular energy
homeostasis which plays a role in fertility. Complete disruption of the AMPK catalytic subunit …

Impact of 5'-amp-activated protein kinase on male gonad and spermatozoa functions

TMD Nguyen - Frontiers in Cell and Developmental Biology, 2017 - frontiersin.org
As we already know, the male reproductive system requires less energetic investment than
the female one. Nevertheless, energy balance is an important feature for spermatozoa …

Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents

S Minabe, C Deura, K Ikegami, T Goto, M Sanbo… - …, 2015 - academic.oup.com
Ependymocytes are one of the energy-sensing cells that regulate animal reproduction
through their responsiveness to changes in extracellular glucose levels and the expression …

AMPK, regulator of sperm energy and functions

TM Nguyen, P Froment, Y Combarnous… - … Sciences: M/S, 2016 - europepmc.org
The 5'-AMP-activated protein kinase, AMPK, is a key protein kinase in the metabolism of the
cell that regulates many metabolic pathways. The involvement of cell metabolism in sperm …