Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer.
These mutations include p53-inactivating mutations as well as oncogenic gain-of-function …

Normal development, tissue homeostasis and regeneration following injury rely on the
proper functions of wide repertoire of stem cells (SCs) persisting during embryonic period …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained
a mystery whether p53 is active in this cell type. We show that a significant part of p53 is …

p53 is well recognized as a potent tumor suppressor. In its classic role, p53 responds to
genotoxic insults by inducing cell cycle exit or programmed cell death to limit the …

Abstract p53 is one of the most studied genes in cancer biology, and mutations in this gene
may be predictive for the development of many types of cancer in humans and in animals …

p53 is a well-known tumor suppressor that is mutated in over 50% of human cancers. These
mutations were shown to exhibit gain of oncogenic function compared with the deletion of …

More than half of human tumors harbor an inactivated p53 tumor-suppressor gene. It is well
accepted that mutant p53 shows an oncogenic gain-of-function (GOF) activity that facilitates …

Impairment of the prominent tumor suppressor p53, well known for its canonical role as the
“guardian of the genome”, is found in almost half of human cancers. More recently, p53 has …

Aging is the single most common risk factor for cancer. Peripheral and marrow-derived stem
cells are long lived and are candidate cells for the cancer-initiating cell. Repeated rounds of …